Announcement PDF Avecho Biotechnology Limited | ASX:AVE | ACN: 056 482 403 | ABN: 32 056 482 403 Unit 8A, 2A Westall Road, Hallmarc Business Park, Clayton VIC Australia 3168 avecho.com.au 21 October 2026 Melissa Kostopoulos ASX Supervision Level 45, South Tower Rialto 525 Collins Street Melbourne VIC 3000 (By email: listingssupervisionmelbourne@asx.com.au) Dear Melissa, AVECHO BIOTECHNOLOGY LIMITED (ASX: AVE) – PRICE QUERY In reference to your letter of 21 October 2026 regarding the price and volume of the Company’s securities, the responses to your queries in number order are as follows: 1. The Company is not aware of any information concerning it that has not been announced to the market which, if known by some in the market, could explain the recent trading in its securities. 2. Not applicable. 3. There is no explanation that the Company has for the recent trading in its securities. 4. We confirm that the Company is in compliance with the listing rules and, in particular, Listing Rule 3.1. 5. It is confirmed that the responses to the questions above have been authorised and approved by the Board of the Company. Please do not hesitate to contact me if you would like to discuss any of the above matters. Yours sincerely, Naomi Lawrie Company Secretary Avecho Biotechnology Limited 34 8.0 1/2 #11160061v1 21 October 2026 Ms Naomi Lawrie Company Secretary Avecho Biotechnology Limited Unit A8, Westall Road Clayton, Vic 3168 By email: Naomi.Lawrie@vistra.com Dear Ms Lawrie Avecho Biotechnology Limited (‘AVE’): Price Query ASX refers to the following: A. The change in the price of AVE’s securities from a low of $0.014 at close of trade on 20/10/2026 to a high of $0.019 today at the time of writing. B. The significant increase in the volume of AVE’s securities traded today. Request for information In light of this, ASX asks AVE to respond separately to each of the following questions and requests for information: 1. Is AVE aware of any information concerning it that has not been announced to the market which, if known by some in the market, could explain the recent trading in its securities? 2. If the answer to question 1 is ‘yes’. (a) Is AVE relying on Listing Rule 3.1A not to announce that information under Listing Rule 3.1? Please note that the recent trading in AVE’s securities would suggest to ASX that such information may have ceased to be confidential and therefore AVE may no longer be able to rely on Listing Rule 3.1A. Accordingly, if the answer to this question is “yes”, you need to contact us immediately to discuss the situation. (b) Can an announcement be made immediately? Please note, if the answer to this question is ‘no’, you need to contact us immediately to discuss requesting a trading halt (see below). (c) If an announcement cannot be made immediately, why not and when is it expected that an announcement will be made? 3. If the answer to question 1 is ‘no’, is there any other explanation that AVE may have for the recent trading in its securities? 4. Please confirm that AVE is complying with the Listing Rules and, in particular, Listing Rule 3.1. 5. Please confirm that AVE’s responses to the questions above have been authorised and approved under its published continuous disclosure policy or otherwise by its board or an officer of AVE with delegated authority from the board to respond to ASX on disclosure matters. When and where to send your response This request is made under Listing Rule 18.7. Your response is required as soon as reasonably possible and, in any event, by no later than 3:30 PM AEDT Wednesday, 21 October 2026. You should note that if the information requested by this letter is information required to be given to ASX under Listing Rule 3.1 and it does not fall within the exceptions mentioned in Listing Rule 3.1A, AVE’s 2/2 #11160061v1 obligation is to disclose the information ‘immediately’. This may require the information to be disclosed before the deadline set out in the previous paragraph and may require AVE to request a trading halt immediately. Your response should be sent by e-mail to listingssupervisionmelbourne@asx.com.au. It should not be sent directly to the ASX Market Announcements Office. This is to allow us to review your response to confirm that it is in a form appropriate for release to the market, before it is published on the ASX Market Announcements Platform. Trading halt If you are unable to respond to this letter by the time specified above, or if the answer to question 1 is “yes” and an announcement cannot be made immediately, you should discuss with us whether it is appropriate to request a trading halt in AVE’s securities under Listing Rule 17.1. If you wish to request a trading halt, you must tell us: • the reasons for the trading halt; • how long you want the trading halt to last; • the event you expect to happen that will end the trading halt; • that you are not aware of any reason why the trading halt should not be granted; and • any other information necessary to inform the market about the trading halt, or that we ask for. We require the request for a trading halt to be in writing. The trading halt cannot extend past the commencement of normal trading on the second day after the day on which it is granted. You can find further information about trading halts in Guidance Note 16 Trading Halts and Voluntary Suspensions. Suspension If you are unable to respond to this letter by the time specified above, ASX will likely suspend trading in AVE’s securities under Listing Rule 17.3.1. Listing Rules 3.1 and 3.1A In responding to this letter, you should have regard to AVE’s obligations under Listing Rules 3.1 and 3.1A and also to Guidance Note 8 Continuous Disclosure: Listing Rules 3.1 – 3.1B. It should be noted that AVE’s obligation to disclose information under Listing Rule 3.1 is not confined to, nor is it necessarily satisfied by, answering the questions set out in this letter. Release of correspondence between ASX and entity ASX reserves the right to release all or any part of this letter, your reply and any other related correspondence between us to the market under Listing Rule 18.7A. The usual course is for correspondence to be released to the market. 1731 15.0 Kind regards ASX Supervision