Announcement PDF Appendix 3Z Final Director’s Interest Notice Rule 3.19A.3 Appendix 3Z Final Director’s Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/9/2001. Name of entity AVECHO BIOTECHNOLOGY LIMITED ABN 32 056 482 403 We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act. Name of director David Segal Date of last notice 3 March 2017 Date that director ceased to be director 31 May 2021 Part 1 – Director’s relevant interests in securities of which the director is the registered holder In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part. Number & class of securities 11,795,920 Fully Paid Ordinary Shares (AVE) 1,500,000 unlisted Options (AVEAS) + See chapter 19 for defined terms. 11/3/2002 Appendix 3Z Page 1 Appendix 3Z Final Director’s Interest Notice Part 2 – Director’s relevant interests in securities of which the director is not the registered holder Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part. In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Name of holder & nature of interest Number & class of securities Note: Provide details of the circumstances giving rise to the relevant interest Mrs Danielle Segal 6,200,000 Fully Paid Ordinary Shares (AVE) Densville Pty Ltd 495,361 Fully Paid Ordinary Shares (AVE) Part 3 – Director’s interests in contracts Detail of contract N/A Nature of interest N/A Name of registered holder (if issued securities) N/A No. and class of securities to which interest relates N/A + See chapter 19 for defined terms. Appendix 3Z Page 2 11/3/2002