Announcement PDF Appendix 3Y Change of Director’s Interest Notice Rule 3.19A.2 Appendix 3Y Change of Director’s Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/09/01 Amended 01/01/11 Name of entity: Avecho Biotechnology Limited ABN 32 056 482 403 We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act. Name of Director Gregory Collier Date of last notice 31 May 2021 Part 1 - Change of director’s relevant interests in securities In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part. Direct or indirect interest Indirect Nature of indirect interest (including registered holder) Gregory Collier is a Director of Beacon Super Fund Pty Ltd <Beacon Super Fund A/c> and a beneficiary if the fund. Note: Provide details of the circumstances giving rise to the relevant interest. Date of change 10 September 2021 No. of securities held prior to change Direct 5,990,465 unlisted options exercisable at $0.0169 each and expiring on 29 November 2024. Indirect Beacon Super Fund Pty Ltd <Beacon Super Fund A/c> 2,000,000 Fully Paid Ordinary Shares 2,250,000 Unlisted Options (Gregory Collier is a Director of the entity and a beneficiary if the fund). Class Unlisted Options expired on 10 September 2021 Number acquired N/A Number disposed 2,250,000 + See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 1 Appendix 3Y Change of Director’s Interest Notice Value/Consideration NIL Note: If consideration is non-cash, provide details and estimated valuation No. of securities held after change Direct 5,990,465 unlisted options exercisable at $0.0169 each and expiring on 29 November 2024. Indirect Beacon Super Fund Pty Ltd <Beacon Super Fund A/c> 2,000,000 Fully Paid Ordinary Shares Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back The 2,250,000 unlisted options expired on 10 September 2021 without being exercised. Part 2 – Change of director’s interests in contracts Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part. Detail of contract N/A Nature of interest N/A Name of registered holder (if issued securities) N/A Date of change N/A No. and class of securities to which N/A interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed Interest acquired N/A Interest disposed N/A Value/Consideration N/A Note: If consideration is non-cash, provide details and an estimated valuation Interest after change N/A + See chapter 19 for defined terms. Appendix 3Y Page 2 01/01/2011 Appendix 3Y Change of Director’s Interest Notice Part 3 – +Closed period Were the interests in the securities or contracts detailed No above traded during a +closed period where prior written clearance was required? If so, was prior written clearance provided to allow the trade N/A to proceed during this period? If prior written clearance was provided, on what date was this provided? + See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 3 N/A